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How is pulmonary artery pressure measured in rabbits?
Rabbit heart lung blocks were isolated, flushed in vivo, harvested, immediately perfused with whole blood, and ventilated with 50% oxygen. Pulmonary artery pressure was determined every 15 seconds for 90 minutes of perfusion.
How is the lung harvested in a rabbit?
Using our isolated, ventilated, blood-perfused rabbit lung model, all groups underwent lung harvest followed by 10-h storage (4 degrees C) and blood reperfusion for 30 min. Group I lungs (n = 5) served as controls. In group II lungs (n = 5), both lung and blood donors received PDTC (100 mg/kg) intravenously 30 min before harvest.
How are rabbits used in the cardiovascular system?
Though most molecular investigations of the cardiovascular system have used transgenic mice, the small rodents do not accurately reflect crucial facets of human cardiovascular physiology, therefore a number of different transgenic rabbit models of hypertrophic cardiomyopathy were created.
How are rabbits used as models for medical research?
Several characteristics of rabbit made it the first and classical model for the study of lipoproteins and atherosclerosis. Rabbit models include normal cholesterol-fed rabbits, spontaneous mutants for lipid metabolism and transgenic rabbits.
Last Update: Oct 2021
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